French-born Alexander Placide managed the Charleston Theatre. Caroline Placide made her stage debut there at the age of three, playing one of the title characters' children in the pantomimeMedea and Jason, and appeared in many other roles in Charleston and New York City throughout her childhood.[2]Noah Ludlow later wrote "she was almost cradled on the stage."[4]
In 1814, at the age of sixteen, she married the comic actor Leigh Waring. He died in 1816. They had one child, the actress Anne Duff Waring Sefton Wallack.[3]
In 1824, she played a leading role in the premiere of the ballad operaThe Saw-Mill; or a Yankee Trick by Micah Hawkins at the Chatham Garden Theatre. The Saw-Mill is often cited as the first American opera. Also appearing in the opera was a Canadian actor seven years her junior, William Rufus Blake.[5][6] In 1826, she and Blake married. Over the next four decades they performed together and managed theatres in the US and Canada.[3] Notable leading roles they played together include Sir Peter Teazle and Lady Teazle in The School for Scandal.[7]
Her last stage appearance was at the Winter Garden Theatre in 1862. She retired after her husband died the next year.[3]