CYP305M2

Identifiers
Organism	Locusta migratoria
Symbol	CYP305M2
UniProt	A0A410UD22
Other data
EC number	1.14.-.-
Search for Structures Swiss-model Domains InterPro

CYP305M2 (formerly called LM16181) is a cytochrome P450 enzyme found in migratory locust (Locusta migratoria) that catalyzes the key step of biosynthesis of phenylacetonitrile (PAN).^[1][2] PAN in turn is used as an aposematic chemical defense against predators.

Biosynthesis of phenylacetonitrile catalyzed by CYP305M2 and subsequent decomposition to benzaldehyde and cyanide

References

1. Wei J, Shao W, Cao M, Ge J, Yang P, Chen L, Wang X, Kang L (January 2019). "Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor". Science Advances. 5 (1): eaav5495. Bibcode:2019SciA....5.5495W. doi:10.1126/sciadv.aav5495. PMC 6357733. PMID 30746481.
2. "Cytochrome P450 [Locusta migratoria]". NCBI Protein. National Center for Biotechnology Information, U.S. National Library of Medicine.