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CSI may refer to:

Arts, entertainment, and media

CSI Sanatan, 2023 Indian Telugu-language film by Sivashankar Dev
Carnaby Street (radio programme), Saturday morning Manx Radio broadcast featuring music and news from the 1960s

Centre for Social Impact, a network of research centres across four Australian universities
Centre for Social Innovation, a social enterprise based in Toronto, Canada
Centre for Social Investigation, an interdisciplinary research group in Oxford, England
City Supermarket, Inc., a grocery chain based in Pangasinan, Philippines
Coimisiún Sábháilteachta Iarnróid, the Railway Safety Commission of Ireland
Computer Security Institute, a former professional association in the United States
Computer Society of India, a professional association
Computers and Structures, Inc., a structural engineering software company
Construction Specifications Institute, a technical society in the United States
Crime Stoppers International

Civilian Saucer Intelligence, an unidentified flying object research group
Committee for Skeptical Inquiry, an organization for skeptical paranormal investigation

Companion of the Order of the Star of India, a class of the order of chivalry founded by Queen Victoria
Cross of Solomon Islands, a class of the Order of the Solomon Islands

Canadian Securities Institute, a financial education company providing professional credentials and compliance courses
Cité Scolaire Internationale de Grenoble, an international school in Grenoble, France
Cité Scolaire Internationale de Lyon, an international school in Lyon, France
College of Southern Idaho, a community college in the United States
College of Staten Island, part of The City University of New York in the United States

Commission Sportive Internationale, a governing body for motor racing
Concours de Saut International, a ranking system for show jumping
CueSports International, a pool (pocket billiards) event promotion company and league organizer, affiliated with the Billiard Congress of America

Camera Serial Interface, an MIPI Alliance protocol for cameras and mobile devices
Channel state information, a wireless communication term
Coherence scanning interferometry, an areal surface topography technique related to 3D interference microscopy
Common System Interface, a former name of the Intel QuickPath Interconnect, a computer bus
Control Sequence Introducer, a control character for initiating escape sequences
Crystalline silicon (c-Si), used in solar cell technology
Conditional symmetric instability, a form of convective instability in a fluid

California Solar Initiative, a renewable energy program
Chlorosulfonyl isocyanate
Complex specified information, an argument for intelligent design
Container Security Initiative, a program of the U.S. Bureau of Customs and Border Protection
CSI 300 Index, a stock market index compiled by the China Securities Index Company
Customer satisfaction index, a metric that reflects the overall customer satisfaction with a company in terms of product quality, customer service, price, etc.