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CRC may refer to:

Science and technology

Carboniferous Rainforest Collapse, an event at the end of the Carboniferous period
Class-responsibility-collaboration card, used as a brainstorming tool in the design of object-oriented software
Clinical research coordinator, responsible for conducting clinical trials
Colorectal cancer, the development of cancer in the colon or rectum
CRC Energy Efficiency Scheme, formerly the Carbon Reduction Commitment, a UK wide scheme designed to increase energy efficiency in large energy users
CRC Handbook of Chemistry and Physics, a science reference handbook published by CRC Press
CRC Standard Mathematical Tables, a mathematics reference handbook published by CRC Press
Cyclic redundancy check, a type of hash function used to produce a checksum in order to detect errors in data storage or transmission

California Rehabilitation Center, a state prison in the United States Of America
Canadian Red Cross
Capital Research Center, an American conservative non-profit organization
Central Revolutionary Committee (French: Comité révolutionnaire central), an extinct French political party
Civilian Response Corps, deployable American federal civilian employees who provide reconstruction and stabilization assistance
Commission for Rural Communities, a United Kingdom public body
Committee on the Rights of the Child, which reports on implementation of the UN Convention on the Rights of the Child
- Convention on the Rights of the Child, of the United Nations
Communications Research Centre Canada, an agency of Industry Canada
Communist, Republican, and Citizen Group, a French parliamentary group
Community Rehabilitation Company, a private-sector suppliers of offender rehabilitation services in England and Wales
Constitutional Research Council, a Unionist, pro-Brexit funding organisation in Scotland and Northern Ireland
Control and Reporting Centre, part of the Air Force control and reporting system in most NATO countries
Civil Rights Congress, a United States civil rights organization from 1946 until 1956

Cambridge Regional College, a further education college
Center for Research and Communication, a Philippine think-tank that later became the University of Asia and the Pacific
Cooperative Research Centre, a type of hybrid academic/industry research body existing in Australia
Cosumnes River College, a two-year community college in Sacramento, California
Crowley's Ridge College, a Christian college in Paragould, Arkansas
Cyclotron Research Center and Cyclotron Resource Center, particle accelerator complex at the University of Louvain, Belgium
Georgia Tech Campus Recreation Center, the Rec center at Georgia Tech

California Resources Corporation, a petroleum and natural gas company
Chicago Recording Company, a recording studio in Chicago
China Record Corporation, a large record company, based in Beijing
China Resources (operated CRC Supermarkets)
China Resources Cement, a cement company parented by China Resources
Columbia Record Club, a mail-order music club offered by Columbia Records
Computer Research Corporation, an early minicomputer manufacturer
CRC-Evans, a pipeline-construction company owned by Stanley Black & Decker
CRC Health Group, provider of addiction treatment and educational programs for adults and youth
CRC Industries, a worldwide manufacturer of specialist industrial chemicals
CRC Press, publisher, originally the Chemical Rubber Company
Customer relation centre, a common company department