CPA5

CPA5
Identifiers
Aliases	CPA5, carboxypeptidase A5
External IDs	OMIM: 609561; MGI: 1921899; GeneCards: CPA5
Gene location (Human)
Chr.	Chromosome 7 (human)
End	130,368,730 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	30,631,744 bp
RNA expression pattern
	Top expressed in
	testicle; ; right testis; ; left testis; ; sperm; ; gonad; ; lymph node; ; body of pancreas; ; pituitary gland; ; anterior pituitary; ; spleen;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; embryo; ; embryo; ; morula; ; yolk sac; ; genital tubercle; ; islet of Langerhans; ; trachea;
	More reference expression data
	n/a
Gene ontology
Molecular function	carboxypeptidase activity; zinc ion binding; peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metallocarboxypeptidase activity;
Cellular component	extracellular region; extracellular space;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	93979
	74649
	ENSG00000158525
	ENSMUSG00000029788
	Q8WXQ8
	Q8R4H4
	NM_001127441; NM_001127442; NM_080385; NM_001318223
	NM_144537
	NP_001120913; NP_001120914; NP_001305152; NP_525124
	NP_653120
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene.^[5]^[6]

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158525 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029788 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD (Apr 2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family". J Biol Chem. 277 (17): 14954–64. doi:10.1074/jbc.M112254200. PMID 11836249.
^ ^a ^b "Entrez Gene: CPA5 carboxypeptidase A5".

External links

Human CPA5 genome location and CPA5 gene details page in the UCSC Genome Browser.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Bentley L, Nakabayashi K, Monk D, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome". J. Med. Genet. 40 (4): 249–56. doi:10.1136/jmg.40.4.249. PMC 1735416. PMID 12676894.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bonora E, Bacchelli E, Levy ER, et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region". Mol. Psychiatry. 7 (3): 289–301. doi:10.1038/sj.mp.4001004. PMID 11920156. S2CID 13282515.
"A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium". Hum. Mol. Genet. 7 (3): 571–8. 1998. doi:10.1093/hmg/7.3.571. hdl:11858/00-001M-0000-0012-C9D8-C. PMID 9546821.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158525 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029788 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11836249-5] Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD (Apr 2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family". J Biol Chem. 277 (17): 14954–64. doi:10.1074/jbc.M112254200. PMID 11836249.

[entrez-6] "Entrez Gene: CPA5 carboxypeptidase A5".

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CPA5

References

External links

Further reading

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