CLEC1A

51267

CLEC1A
CLEC1A
Identifiers
AliasesCLEC1A, CLEC-1, CLEC1, C-type lectin domain family 1 member A
External IDsOMIM: 606782; MGI: 2444151; GeneCards: CLEC1A
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

51267

243653

Ensembl

ENSG00000150048

ENSMUSG00000033082

UniProt

Q8NC01

Q8BWY2

RefSeq (mRNA)

NM_001297748
NM_001297749
NM_001297750
NM_001297751
NM_016511

NM_175526
NM_001347475

RefSeq (protein)

NP_001334404
NP_780735

Location (UCSC)Chr 12: 10.07 – 10.11 MbChr 6: 129.4 – 129.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.[5][6][7]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150048 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033082 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol. 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229.
  6. ^ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol. 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369. S2CID 42415487.
  7. ^ a b "Entrez Gene: CLEC1A C-type lectin domain family 1, member A".

Further reading


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