C-sis internal ribosome entry site (IRES)

c-sis internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_c-sis
Identifiers
Symbol	IRES_c-sis
Rfam	RF00549
Other data
RNA type	Cis-reg; IRES
Domain(s)	Eukaryota
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe

The c-sis internal ribosome entry site (IRES) is a RNA element found in the 5' UTR of the PDGF beta chain gene. The internal ribosome entry site contains three modules that can individually mediate internal ribosome entry. However, the full length sequence is required for maximal IRES activity. It is thought that the three IRES elements are somehow responsive to cellular changes and act to regulate the level of translation.^[1]

References

1. Sella O, Gerlitz G, Le SY, Elroy-Stein O (August 1999). "Differentiation-induced internal translation of c-sis mRNA: analysis of the cis elements and their differentiation-linked binding to the hnRNP C protein". Molecular and Cellular Biology. 19 (8): 5429–5440. doi:10.1128/mcb.19.8.5429. PMC 84385. PMID 10409733.

External links

• Page for c-sis internal ribosome entry site (IRES) at Rfam