After redshirting his first year at Washington in 2016, Murphy played in six games with six starts in 2017, missing seven due to injury. He finished the season with 16 tackles and three interceptions.[3][4][5] He returned to Washington as a starter in 2018.[6] He was awarded the MVP at the 2018 Pac-12 Football Championship Game after making two interceptions, one of which he returned for a 66-yard touchdown.[7] On January 7, 2019, Murphy announced that he would forgo his remaining two years of eligibility and declare for the 2019 NFL draft.[8]
The Arizona Cardinals selected Murphy in the second round (33rd overall) of the 2019 NFL Draft.[12] Murphy was the second cornerback drafted in 2019 and the fourth defensive back overall.
On May 9, 2019, the Arizona Cardinals signed Murphy to a four-year, $7.98 million contract that includes $5.63 million guaranteed and a signing bonus of $3.83 million.[13] Throughout training camp, Murphy competed against Tramaine Brock and Chris Payton-Jones for the job as the second starting cornerback or Nickelback after Patrick Peterson was given a six-game suspension to begin the season. Head coach Kliff Kingsbury named Murphy a starting cornerback, alongside Tramaine Brock, to begin the 2019 regular season.[14]
On September 8, 2019, Murphy made his professional regular season debut and first career start,asking 5 combined tackles (4 solo) during a 27–27 tie with the Detroit Lions. In week 10 against the Tampa Bay Buccaneers, Murphy recorded his first career interception off Jameis Winston in the 30–27 loss.[15]
In Week 7 of the 2020 season against the Seattle Seahawks on Sunday Night Football, Murphy recorded his first career sack on Russell Wilson during the 37–34 overtime win.[16] He was placed on the reserve/COVID-19 list by the team on November 2, 2020,[17] and activated on November 11.[18]
Murphy entered the 2021 season as a starting cornerback for the Cardinals. In Week 3 of the 2021 season, he had two interceptions, including a 29-yard pick-six in a 31–19 win over the Jaguars, earning National Football Conference Defensive Player of the Week.[19] He finished the season with 64 tackles and a team-leading 12 passes defensed and four interceptions.
Murphy returned as a starting cornerback for the Cardinals in 2022. In Week 2, he returned a fumble forced by Isaiah Simmons 59 yards for the game-winning touchdown in a 29–23 overtime win against the Las Vegas Raiders. On December 24, 2022, the Cardinals placed Murphy on season–ending injured reserve with a back injury that had kept him out since Week 10.[20] He finished the season with 36 tackles, four passes defensed, and two fumble recoveries through nine starts.
Minnesota Vikings
On March 15, 2023, the Minnesota Vikings signed Murphy to a two-year, $17.50 million contract that includes $12.60 million guaranteed and a signing bonus of $7.00 million.[21][13]