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A bubo is a rounded swelling on the skin of a person afflicted by the bubonic plague.

Bubo may also refer to:

Bubo (bird), the horned owl and eagle-owl genus
- Bubo, a Great Horned Owl in the Guardians of Ga'Hoole book series and the 2010 film adaptation Legend of the Guardians: The Owls of Ga'Hoole
- Bubo, Athena's owl (after which she also names the mechanical owl she gifts Perseus) in the 1981 film Clash of the Titans
- Bubo, a Muppet owl on Barrio Sésamo
Bubo, Duke of the Frisians (died 734)
Bubo (fish trap)
Bubo, a character in the television series The Trap Door
Bubo, short for Buboicullaar, a Star Wars alien from Return of the Jedi who was later featured in Tales From Jabba's Palace as the star of one of many short stories

This disambiguation page lists articles associated with the title Bubo.
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Bubo (disambiguation)