A bipolar neuron, or bipolar cell, is a type of neuron characterized by having both an axon and a dendrite extending from the soma (cell body) in opposite directions. These neurons are predominantly found in the retina and olfactory system.[1] The embryological period encompassing weeks seven through eight marks the commencement of bipolar neuron development.[2]
Bipolar neurons, classified as second-order retinal neurons, play a crucial role in translating responses to light into a neural code for vision.[5]
Often found in the retina, bipolar cells are crucial as they serve as both direct and indirect cell pathways. The specific location of the bipolar cells allow them to facilitate the passage of signals from where they start in the receptors to where they arrive at the amacrine and ganglion cells. Bipolar cells in the retina are also unusual in that they do not fire impulses like the other cells found within the nervous system. Rather, they pass the information by graded signal changes. Bipolar cells convey impulses from photoreceptors (rods and cones) to ganglion cells, [6] which in turn transport the visual signals to the brain through the optic nerve. Bipolar cells come in two varieties, having either an on-center or an off-center receptive field, each with a surround of the opposite sign. The off-center bipolar cells have excitatory synaptic connections with the photoreceptors, which fire continuously in the dark and are hyperpolarized (suppressed) by light. The excitatory synapses thus convey a suppressive signal to the off-center bipolar cells. On-center bipolar cells have inhibitory synapses with the photoreceptors and therefore are excited by light and suppressed in the dark.[7]
In the vestibular nerve
Bipolar neurons exist within the vestibular nerve as it is responsible for special sensory sensations including hearing, equilibrium and motion detection. The majority of the bipolar neurons belonging to the vestibular nerve exist within the vestibular ganglion with axons extending into the maculae of utricle and saccule as well as into the ampullae of the semicircular canals.[8]
In the spinal ganglia
Bipolar cells are also found in the spinal ganglia, when the cells are in an embryonic condition.
Sometimes the extensions, also called processes, come off from opposite poles of the cell, and the cell then assumes a spindle shape.
In some cases where two fibers are apparently connected with a cell, one of the fibers is really derived from an adjoining nerve cell and is passing to end in a ramification around the ganglion cell, or, again, it may be coiled helically around the nerve process which is issuing from the cell.
In the cerebral cortex
Von Economo neurons, also known as spindle neurons, found in a few select parts of the cerebral cortex of apes and some other intelligent animals, possess a single axon and dendrite and as such have been described as bipolar.[9][10]
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References
^Muzio, M. R., & Cascella, M. (2022). Histology, Axon. In StatPearls. StatPearls Publishing.
^Ahimsadasan N, Reddy V, Khan Suheb MZ, et al. Neuroanatomy, Dorsal Root Ganglion. [Updated 2022 Sep 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532291/
^Vanderah, Todd W.; Gould, Douglas J.; Nolte, John (2015). Nolte's The Human Brain : An Introduction to Its Functional Anatomy (7th ed.). Philadelphia, Pennsylvania: Elsevier. ISBN9781455728596. OCLC895731173.
^"bipolar cell". Medical Dictionary for the Health Professions and Nursing. Farlex. 2012. Retrieved 17 January 2024 – via TheFreeDictionary by Farlex.
^Thoreson W. B. (2021). Transmission at rod and cone ribbon synapses in the retina. Pflugers Archiv : European journal of physiology, 473(9), 1469–1491. https://doi.org/10.1007/s00424-021-02548-9
^Nelson, R., & Connaughton, V. (2007). Bipolar Cell Pathways in the Vertebrate Retina. In H. Kolb (Eds.) et. al., Webvision: The Organization of the Retina and Visual System. University of Utah Health Sciences Center.