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The "Big Three" usually describes the three most prominent entities in any given grouping or subject. It may refer to:

Arts and entertainment

Big Three (American television), the three major traditional commercial broadcast television networks in the United States (ABC, CBS, and NBC)
Big Three (record labels), major record labels (Universal, Sony, Warner)
"The Big 3" or Robbins, Feist & Miller (1934-1973), music publishing division of Metro-Goldwyn-Mayer
The Big Three (English band)
The Big 3 (folk group), a folk trio comprising Cass Elliot, Tim Rose, and James Hendricks
The Big Three, an R&B ensemble led by Willie Dixon
The Big 3 (Milt Jackson album), 1975

Big Three (Belgium), the three most successful association football clubs in Belgium
Big Three (Costa Rica), the three most successful association football clubs in Costa Rica
Big Three (Greece), the three most successful association football clubs in Greece
Big Three (India), in the Calcutta Football League, Mohammedan SC (Kolkata), East Bengal FC, Mohun Bagan
Big Three (Netherlands), the three most successful association football clubs in the Netherlands
Big Three (Peru), the three most successful association football clubs in Peru
Big Three (Portugal), the three most successful association football clubs in Portugal
Big Three (Sweden), the three most successful association football clubs in Sweden
Big Three (Turkey), the three most successful association football clubs in Turkey

Big3, a professional 3-on-3 basketball league
Big Three (Boston Celtics, 1980–1992), Larry Bird, Kevin McHale, and Robert Parish
Big Three (Boston Celtics, 2007–2012), Kevin Garnett, Ray Allen, and Paul Pierce
Big Three (San Antonio Spurs), Tim Duncan, Tony Parker, and Manu Ginóbili
Big Three (Miami Heat), LeBron James, Dwyane Wade, and Chris Bosh

Big Three (cricket), members of the International Cricket Council, England Cricket Board, Board of Control for Cricket in India and Cricket Australia
Big Three (tennis), Novak Djokovic, Rafael Nadal, and Roger Federer
Big Three (colleges), Harvard University, Yale University, and Princeton University
Big Three (hurling), the hurling county teams of Cork, Kilkenny, and Tipperary
Big Three (Atlanta Braves), Tom Glavine, Greg Maddux, and John Smoltz
Big Three (Oakland Athletics), Tim Hudson, Mark Mulder, and Barry Zito
Big Three, Penn State, Pittsburgh, and West Virginia football teams symbolized by the Old Ironsides Trophy

Big Three (automobile manufacturers), a country's three largest automobile manufacturers
Big Three (credit rating agencies), S&P Global, Moody's Investors Service, and Fitch Ratings
Big Three (management consultancies), McKinsey & Company, Boston Consulting Group, and Bain & Company
Big Three (World War II), Franklin Roosevelt, Winston Churchill, and Joseph Stalin during World War II
Big Three (Maine colleges), Colby-Bates-Bowdoin Consortium