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Big Four or Big 4 may refer to:

Groups of companies

Big Four accounting firms: Deloitte, Ernst & Young, KPMG, PwC
Big Four (airlines) in the U.S. in the 20th century: American, Eastern, TWA, United
Big Four (banking), several groupings of banks in different countries
Big Four (British railway companies) in the period 1923–1947: GWR, LMS, LNER, SR
Big Four (radio networks) in the U.S.: CBS, NBC, ABC, Mutual
Big Four Railroad, a nickname of the Cleveland, Cincinnati, Chicago and St. Louis Railway in the U.S.
The "Big Four" Big Tech companies: Apple, Amazon, Google, Meta Platforms
Big Four television networks in the U.S.: ABC, CBS, DuMont/FOX, NBC
The "Big Four" largest UK ITV companies 1955–1968: History of ITV § The Big Four and Big Five
Japanese Big Four motorcycle manufacturers: Honda, Kawasaki, Suzuki, Yamaha

Big Four (Central Pacific Railroad), 19th century American railroad entrepreneurs
Big Four (debutantes), in the Chicago social scene during World War I
Big Four (Najaf), leading Grand Ayatollahs of Twelver Shia Islam
The Four Companions, the most loyal companions of Muhammad and Ali
Big Four (Scotland Yard), London detectives of about 1919
Big Four of Maryland Thoroughbred racing, horse trainers in the 1960s–1970s
The Big Four (Calgary), Alberta cattlemen of the early 20th century
The Four Greats (Norwegian writers): Ibsen, Bjørnson, Lie, Kielland

Big Four (Canadian football), a forerunner competition to the Canadian Football League East Division
Big Four (English football) in the 2000s: Arsenal, Chelsea, Liverpool, Manchester United
Big Four (Mexico), a group of the top four football clubs in Mexico: Club América, Chivas, Cruz Azul and Pumas
Big Four (polo), an American polo team of the early 20th century
Big Four (tennis), from 2008 to 2017: Federer, Nadal, Djokovic, Murray
Big Four, the leading major professional sports leagues in the United States and Canada: MLB, NBA, NFL, NHL
Big-4 League, a senior ice hockey league in Canada between 1919 and 1921

Big Four (Western Europe): France, Germany, Italy, and the United Kingdom
Big Four Conference, various conferences between the victorious nations after World War I and World War II
Big Four (World War I), the four major Allied powers: United States, United Kingdom, France, Italy
Big Four (World War II), or Four Policemen: United States, United Kingdom, China, Soviet Union
Big Four outlaw motorcycle clubs: Hells Angels, Pagans, Outlaws, Bandidos
Big Four international beauty pageants: Miss Earth, Miss International, Miss Universe, and Miss World
Big Four (universities), the top four universities in the Philippines

Big Four (band), a Hong Kong music group
Big Four (Eurovision), the four main sponsoring countries before 2011
Big Four (Grammy Awards) or the General Field, four standard awards
The Big Four (fashion), the 4 most notable Vogue covers: American Vogue, British Vogue, Vogue France and Vogue Italia
The Big Four: Live from Sofia, Bulgaria a 2010 concert recording
Big Four, a key rhythmic innovation on the marching band beat, invented by Buddy Bolden
Big 4 (sculpture), outside the Channel 4 headquarters in London
The Big Four (novel), by Agatha Christie, 1927
The Big 4, a 2022 Indonesian movie
The Big Four of thrash metal: Metallica, Megadeth, Slayer and Anthrax

Big Four, West Virginia, U.S.
Big Four Bridge, connecting Louisville, Kentucky, and Jeffersonville, Indiana, U.S.
Big Four Mountain, Washington, U.S.

Big 4 (lottery), a game in the Pennsylvania Lottery
Big Four (Indian snakes), four snake species responsible for the most snake-bites in India
Big Four (White Star Line), four British ocean liners of the early 20th century
Norton Big 4, a British motorcycle 1907–1954