Sanders first played college football for the South Florida Bulls from 2017 to 2020. He appeared in one game his freshman year in 2017 and made one tackle.[3] He played in 12 games, starting two, in 2018, recording 28 tackles and one forced fumble while also returning 17 kickoffs for 455 yards. Sanders played in 12 games, starting nine, during the 2019 season, totaling 40 tackles, two sacks, two forced fumbles, and three pass breakups while also returning 19 kicks for 425 yards.[3] He appeared in six games, starting four, during the COVID-19 shortened 2020 season, accumulating 25 tackles, one interception and two pass breakups. He also missed three games that year due to "COVID-19 issues".[3]
Sanders transferred to play for the Nevada Wolf Pack from 2021 to 2022.[3] He played in all 13 games, recording 24 tackles and two pass breakups in 2021.[3] He started all 12 games for the Wolfpack during his sixth season of college football in 2022, totaling 82 tackles, five interceptions (one of which was returned for a touchdown), and three forced fumbles, earning first-team All-Mountain West honors.[3][4] Sanders was named an Associated Press midseason All-American and one of 12 semifinalists for the Jim Thorpe Award after co-leading the FBS with five interceptions partway through the 2022 season.[5][6][7][8]