Brieske was assigned to the Toledo Mud Hens of the Triple-AInternational League to begin the 2022 season.[10] After making two starts with Toledo, Brieske's contract was selected by the Tigers on April 22.[11] He made his MLB debut for the Tigers as the starting pitcher on April 23, 2022, in a loss to the Colorado Rockies, pitching five innings in which he allowed three hits, three runs, two walks, and three strikeouts.[12] Brieske earned his first major league win on June 11, throwing 5+2⁄3 scoreless innings in the Tigers' 3–1 victory over the Toronto Blue Jays.[13] On July 21, Brieske was placed on the 15-day injured list with forearm soreness
Brieske returned for spring training in 2023 but ended up back on the injured list before the season started with the same injury that ended his 2022 season.[14] He was activated from the injured list on July 7, 2023.[15] In 25 games for Detroit, Brieske logged a 3.60 ERA with 31 strikeouts and 2 saves across 35 innings pitched.
Brieske was optioned to Triple–A Toledo to begin the 2024 season.[16] In limited duty for the Tigers, he went 4–5 with a 3.59 ERA and 69 strikeouts in 67+2⁄3 innings. In the 2024 postseason, Brieske pitched in six of his team's seven games. He gave up only one hit in the six innings, that hit being a 2-run home run by David Fry.