BDP1

55814

BDP1
BDP1
Identifiers
AliasesBDP1, HSA238520, TAF3B1, TFC5, TFIIIB150, TFIIIB90, TFNR, B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, DFNB112, TFIIIB''
External IDsOMIM: 607012; MGI: 1347077; GeneCards: BDP1
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

55814

544971

Ensembl

ENSG00000274803
ENSG00000273873
ENSG00000145734

ENSMUSG00000049658

UniProt

A6H8Y1
H7C5U4

Q571C7

RefSeq (mRNA)

NM_018429

NM_001081061

RefSeq (protein)

NP_060899

NP_001074530

Location (UCSC)Chr 5: 71.46 – 71.57 MbChr 13: 100.02 – 100.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.[5][6][7]

Function

TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase 2 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.[7]

References

  1. ^ a b c ENSG00000273873, ENSG00000145734 GRCh38: Ensembl release 89: ENSG00000274803, ENSG00000273873, ENSG00000145734 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049658 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  6. ^ Schramm L, Pendergrast PS, Sun Y, Hernandez N (Nov 2000). "Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters". Genes Dev. 14 (20): 2650–63. doi:10.1101/gad.836400. PMC 316990. PMID 11040218.
  7. ^ a b "Entrez Gene: BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB".

Further reading


Stub icon

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.