The railroad and the station, then known as Fisherton Station, were built by British-owned company Central Argentine Railway at the beginning of the 1890s. The neighbourhood, originally built to house the company's workers, grew around the station.[4]
The station was an intermediate stop of the line that started at Rosario Central Station. The trip from this terminus to Fisherton took no more than 15 minutes (a comparable bus trip at present may take 45 minutes). After leaving Fisherton, in the periphery of Rosario's urban area, the line served towns west of the city and reached the city of Córdoba. Around 1935–1940, immediately after the "golden age" of Argentine railways, the station managed around 100,000 passengers a year.[5]
In 1977 most passenger train services of Argentina were eliminated, and Antártida Argentina station was closed as well. The building was left largely abandoned.
The station was restored in the 1990s, though it underwent modifications that have been criticized (e.g. the removal of a protective layer of brick, which may greatly reduce the durability of the building).[6]