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Pavignano had been writing for several years before she really began her professional career. She studied psychology at University of Turin and worked on a television show to pay for her studies. In 1977, she met the actor, director and screenwriter Massimo Troisi on the set of the show Non Stop.[1] Her professional career began with him and on a personal aspect, she found love in Troisi.
Their first film together is I'm Starting from Three[2] in 1981 which was nominated for Best Screenplay at the David di Donatello Awards.[3][4] They wrote Scusate il ritardo in 1983 nominated for several awards for acting. In 1983, they wrote the film Le vie del Signore sono finite which was nominated for Best Screenplay at the Italian National Syndicate of Film Journalist.[5] Their relation ended in 1987, but they kept working together until the death of Troisi. Their major accomplishment was the film Il Postino in 1994. Tragically, just 12 hours after the end of the shooting of the film, Massimo Troisi died of a heart attack. The movie won several awards and was nominated in many categories as well. The film was nominated for the Oscar of Best Writing, Screenplay Based on Material Previously Produced or Published.[6] It was also nominated for Best Screenplay - Adapted at the BAFTA Awards.[7]
After the end of the relationship with Troisi, Pavignano continued her career, working with other writers. She then wrote Passi d'amore in 1989. She wrote, by herself, the film Ma non per sempre in 1991. In 2002, she wrote the screenplay for the film Casomai and was nominated for a David di Donatello Award for Best Screenplay.[1]
She also started writing books in 2007. She started with the book Da domani mi alzo tardi talking about her past relationship with Massimo Troisi. It is a novel using her life as a subject making it a bit of a biography.[1]