Holmes' early work at Cambridge expanded his interest in new techniques for synthesising small molecules that are biologically-active and practically-useful, including natural products (such as alkaloids) and peptidomimetics. In 1989, during systematic characterisation of a newly synthesised conductive polymer, Chloe Jennings working in Holmes' research group observed that the polymer emitted light when a current was passed through it. An intensive period of research in Holmes' group, and other polymer chemistry groups, led to the discovery of differently-coloured light-emitting polymers that spanned the visible colour spectrum. A subsequent collaboration with physicist Richard Friend and co-workers at Cambridge's Cavendish Laboratory revealed the potential of these conjugated polymers for applications such as organic LEDs and rollable displays.[9]
Friend and Holmes co-founded the company Cambridge Display Technology[10] for commercial exploitation of these materials – an early success story of Silicon Fen.
In 2004 Holmes returned to his native Australia on a Federation Fellowship, to lead a group at the newly established Bio21 Institute. He has pursued the application of photovoltaic polymers to solar energy, and was instrumental in forming the Victorian Organic Solar Cell Consortium. He has also continued to develop new syntheses of novel, biologically-useful materials. An example is his groups' synthesis of phosphoinositides, amphiphilicphospholipids situated in the cell membrane, which collaborators at the Ludwig Institute for Cancer Research have used to probe the dynamics of signal transduction (intercellular signalling being an important component of many aspects of cell biology, including that of tumors).[11]
Holmes has served on the editorial or advisory boards of numerous learned scientific journals, including Organic Letters, Chemical Communications and Angewandte Chemie. In 2006, his 1998 paper on electroluminescent polymers was the most highly cited paper in Angewandte Chemie's 120-year history.[12][13] By August 2012 he had authored over 490 scientific papers and 52 patent applications.
In 2014 he was appointed as President of the Australian Academy of Science.[14]
In 2004 he was appointed a Member of the Order of Australia "for service to science through research and development, particularly in the fields of organic synthesis and polymer chemistry";[16] and in 2017 was appointed Companion of the Order of Australia for eminent service to science through developments in the field of organic and polymer chemistry as a researcher, editor and academic, and through the governance of nationally recognised, leading scientific organisations.[17] He was awarded the 2021 Matthew Flinders Medal and Lecture.[18]
Personal life
Holmes is a keen hillwalker and an enthusiastic aficionado of classical music, from baroque to romantic opera.[19] During his time in Cambridge he was a member and regular volunteer at St Columba's United Reformed Church. He lives in Melbourne and Lorne, Victoria with his wife Jennifer.
^ abMang, Stephan; Cooper, Andrew I.; Colclough, M. Eamon; Chauhan, Naren; Holmes, Andrew B. (2000). "Copolymerization of CO2 and 1,2-Cyclohexene Oxide Using a CO2-Soluble Chromium Porphyrin Catalyst". Macromolecules. 33 (2): 303–308. Bibcode:2000MaMol..33..303M. doi:10.1021/ma991162m.
^Holmes, A. B. (1971). The synthesis of large-ring conjugated systems (PhD). University College London. ProQuest301295009.
^A. Holmes; H. Maag; N. Obata; P. Schneider; W. Schilling; J. Schreiber; A. Eschenmoser (1972). "Total Synthese von Vitamin B12". CHIMIA. 26 (320).
^Conway, S. J.; Gardiner, J.; Grove, S. J. A.; Johns, M. K.; Lim, Z. Y.; Painter, G. F.; Robinson, D. E. J. E.; Schieber, C.; Thuring, J. W.; Wong, L. S. -M.; Yin, M. X.; Burgess, A. W.; Catimel, B.; Hawkins, P. T.; Ktistakis, N. T.; Stephens, L. R.; Holmes, A. B. (2010). "Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes". Organic & Biomolecular Chemistry. 8 (1): 66–76. doi:10.1039/b913399b. PMID20024134.