Santiago beat Italy in 2015 Premier12 tournament in Taiwan tossing 7 scoreless innings striking out 6 to give Puerto Rico the first win of the tournament. Santiago later pitch 6+2⁄3 of work against Chinese Taipe striking 5 batters to help Puerto Rico advance to the quarterfinals.
Andres won The Closer Of the Year award in Venezuelan Winter league for Caribes de Anzoategui and the championship in same year (2017).
Santiago has won 2 Caribbean Series Champions while participating in six. His victory over the Dominican Republic in 2018 help Puerto Rico win their Back2Back championship.