Born in Sobreiro Curvo, Torres Vedras, Santos joined Sporting CP's youth system at the age of 11. He made his senior debut while on loan, with C.D. Fátima of the third division[2] and U.D. Leiria;[3] in the 2009–10 season, with the latter, he first appeared in the Primeira Liga, playing 30 complete games to help the club finish in ninth place and being the first Portuguese player to achieve the feat in the league in the process.[4]
Santos returned to the Lions for 2010–11, playing his first official match with the side on 5 August in a 2–1 home win against FC Nordsjælland in the UEFA Europa League.[5] He scored his first goal as a professional exactly four months later, helping the visiting team defeat 3–1 Portimonense SC,[6] and finished the campaign with 42 appearances in all competitions (two goals).[7]
On 25 August 2011, also in the Europa League and against the same Danish opponent, and with the same match result but now in the playoff round, Santos netted to eventually help Sporting reach the group stage as that was also the aggregate score.[8] However, he eventually lost his importance in the squad under new manager Domingos Paciência.[9]
In June 2012, Santos moved alongside a host of compatriots – including Sporting teammate Diogo Salomão – to Deportivo de La Coruña from Spain, in a season-long loan.[10] He made his La Liga debut on 1 September by coming on as a late substitute in a 1–1 home draw with Getafe CF,[11] but featured sparingly overall and the Galicians were also relegated.
^Gomes de Andrade, Maria (4 July 2016). "Oficial: André Santos reforça Arouca" [Official: André Santos bolsters Arouca] (in Portuguese). Mais Futebol. Retrieved 8 September 2020.