Alkermes plc

Alkermes plc
Company typePublic
IndustryBiotechnology
Founded1987; 38 years ago (1987)
FounderMichael Wall
Headquarters
Dublin
,
Ireland[1]
Key people
Richard Pops (CEO)
RevenueIncrease US$1.1 billion (2022)[2]
Decrease US$-20.5 million
Decrease US$-158 million (2022)
Total assetsIncrease US$1.9 billion
Total equityIncrease US$1 billion
Number of employees
2,100
Websitewww.alkermes.com

Alkermes plc is a fully-integrated biopharmaceutical company that focuses on developing medicines for psychiatric and neurological disorders. The company was founded in 1987 by Michael Wall.[3] In September 2011 Alkermes, Inc. merged with Elan Drug Technologies (EDT), the former drug formulation and manufacturing division of Élan Corporation, plc.[4] The company is headquartered in Dublin, and has an R&D center in Waltham, Massachusetts, and a manufacturing facility in Wilmington, Ohio.[1]

Products

Alkermes has four proprietary commercial drug products[5] approved for the treatment of schizophrenia, bipolar I disorder, alcohol dependence and opioid dependence. These include olanzapine and samidorphan (Lybalvi), an atypical antipsychotic and opioid modulator combination intended for the treatment of schizophrenia and bipolar I disorder; aripiprazole lauroxil (Aristada), a long-acting injectable for schizophrenia; and naltrexone for extended-release injectable suspension (Vivitrol) for alcohol and opioid dependence.

Other products utilizing Alkermes' proprietary technologies include: diroximel fumarate (Vumerity) for multiple sclerosis, risperidone (microspheres) long-acting injectable (Risperdal Consta) for schizophrenia and bipolar I disorder, paliperidone palmitate (Invega Sustenna, Invega Trinza and Invega Hafyerain in the U.S., Xeplion, Trevicta and Bynnali in Europe) for schizophrenia.[6][7]

In October 2023, Alkermes announced its first data related to its orexin 2 receptor (OXR2) agonist, ALKS 2680. ALKS 2680 is in development for the treatment of narcolepsy.[8]

In November 2023, Alkermes completed the planned separation of its oncology business into a new company, Mural Oncology, which plans to continue to work on the investigational interleukin-2 (IL-2) drug, nemvaleukin alfa.[9]

In May 2024, Alkermes completed the sale of its Athlone, Ireland facility to Novo Nordisk. [10]

References

  1. ^ a b Robert Weisman (10 May 2011). "Alkermes to buy Irish drug maker". Boston Globe.
  2. ^ "Alkermes PLC".
  3. ^ "Alkermes And Richard Pops — The Evolution Of A Company And Its Leader". LifeScienceLeader.com. 1 May 2019. Retrieved 21 June 2019.
  4. ^ "Alkermes Reels In Elan's Drug Technology Business". Forbes.com. 9 May 2011. Retrieved 13 October 2011.
  5. ^ "Alkermes, Inc. Company Information". Drugs.com. Retrieved 2023-11-22.
  6. ^ "U.S. Third-Party Medicines | Alkermes". www.alkermes.com. Retrieved 2023-11-22.
  7. ^ "Alkermes EU Pharmaceutical Manufacturing Products | Alkermes". www.alkermes.com. Retrieved 2023-11-22.
  8. ^ "Orexin Receptor ALKS 2680 Demonstrates Positive Phase 1 Findings". Neurology live. 2023-11-06. Retrieved 2023-11-22.
  9. ^ "Alkermes separates cancer drug business as new company Mural". BioPharma Dive. Retrieved 2023-11-22.
  10. ^ "Alkermes plc Completes Sale of Athlone, Ireland Facility to Novo Nordisk". alkermes.com. 2024-05-02. Retrieved 2024-06-24.
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