Alfonso d'Avalos d'Aquino, 6th Marquis of Pescara, 2nd Marquis of Vasto (1502 – 31 March 1546), was an Italian condottiero of Aragonese origins, renowned for his service in favour of Charles V, Holy Roman Emperor and King of Spain.
In July 1535, he served as Imperial lieutenant during the reconquest of the city of Tunis in North Africa. The failure of the third war against France trying to invade Provence, and the death of the first Governor of the Duchy of Milan, Antonio de Leyva, prompted him in 1538 to accept the nomination as governor, replacing Marino Caracciolo, the second governor, becoming some sort of protector of literary and musical people [clarification needed]. Wars with the French and North Italians ended for a while with the Treaty of Crespy (1544). He also became a Knight in the Order of the Golden Fleece.
He later represented Emperor Charles V as an ambassador, in 1538, on the succession to the new Doge of the Republic of Venice, Pietro Lando.