On 11 December 2017, Orfila left Comunicaciones to take over second division side Ferro Carril Oeste.[6] He left on a mutual agreement on 9 February 2019,[7] and was named Atlanta manager on 11 March.[8]
Orfila left Atlanta in December 2019,[9] and returned to his first club Defensor, now as manager.[10] He was sacked on 12 November 2020,[11] and returned to Argentina the following 7 February, after being presented at Belgrano.[12]
Dismissed by Belgrano on 8 May 2021,[13] and was announced as manager of Chilean side San Luis de Quillota nine days later.[14] However, he did not take over the latter club,[15] and was appointed manager of Morón on 6 December.[16]
Orfila was relieved from his duties on 16 April 2022,[17] and returned to Atlanta on 2 May.[18] He only lasted six matches at the club, being sacked on 15 June.[19]
On 25 October 2022, Orfila was appointed manager of another club he represented as a player, Almirante Brown.[20] Dismissed the following 11 June,[21] he was announced as manager of Temperley late in the month.[22]
Orfila departed Temperley on 4 December 2023,[23] and was appointed manager of Barracas Central in the Primera División nine days later.[24]