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Against All Odds may refer to:

Film and television

Listed in chronological order

Against All Odds (1924 film), a lost 1924 American silent Western film
Against All Odds, American video title of a 1968 British crime film otherwise known as The Blood of Fu Manchu
Against All Odds (1984 film), a 1984 American film starring Rachel Ward, Jeff Bridges and James Woods
- Against All Odds (soundtrack), the soundtrack from the movie
Against All Odds (2011 film), a 2011 Swiss documentary (German title: Mit dem Bauch durch die Wand)

Against All Odds (TV series), an American reality television series broadcast for four episodes on NBC in 1992
Against All Odds: Lost and Found, a British television film produced by BBC and aired in 1994
Against All Odds, a docudrama TV show, similar to BBC One's 999, which debuted on CBBC in 2000
"Against All Odds" (D:TNG episode), an episode from Degrassi: The Next Generation during the 2003–04 season
TNA Against All Odds, an American annual pay-per-view wrestling event that debuted in 2005
Against All Odds, English title of the 2013 Filipino television series Huwag Ka Lang Mawawala
Against All Odds (Philippine TV series), original title of My Guardian Alien, which debuted in 2024

Listed in chronological order

"Against All Odds (Take a Look at Me Now)", a song by Phil Collins, written for the 1984 film of that name
- "Against All Odds (Take a Look at Me Now)" (Mariah Carey recording), Mariah Carey's rendition of the song, also featuring Westlife, 2000
"Against All Odds", a 1996 song by Tupac Shakur from The Don Killuminati: The 7 Day Theory album
"Against All Odds" (Chase & Status song), from 2009

Against All Odds (biography), a 2017 book about Edgar Lungu by Anthony Mukwita
Against All Odds (novel), a 2017 book by Danielle Steel
Against All Odds (video game), a 2005 browser-based video game by UNHCR
Against All Odds: My Story, an autobiography by Chuck Norris