APBB3

2DYQ, 2YSC

APBB3
APBB3
Identifiers
AliasesAPBB3, FE65L2, SRA, amyloid beta precursor protein binding family B member 3
External IDsOMIM: 602711; MGI: 108404; GeneCards: APBB3
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

10307

225372

Ensembl

ENSG00000113108

ENSMUSG00000117679

UniProt

O95704
Q96DX9

Q8R1C9

RefSeq (mRNA)

NM_146085
NM_001357512

RefSeq (protein)

NP_666197
NP_001344441

Location (UCSC)Chr 5: 140.56 – 140.56 MbChr 18: 36.8 – 36.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Amyloid beta A4 precursor protein-binding family B member 3 is a protein that in humans is encoded by the APBB3 gene.[5][6]

The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113108 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000117679 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (Jan 1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". J Biol Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
  6. ^ a b "Entrez Gene: APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3".

Further reading


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