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RPL14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5AJ0, 4UG0, 4V6X
Identifiers
Aliases	RPL14, CAG-ISL-7, CTG-B33, L14, RL14, hRL14, ribosomal protein L14
External IDs	OMIM: 617414; MGI: 1914365; HomoloGene: 68375; GeneCards: RPL14; OMA:RPL14 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	40,468,587 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	120,403,720 bp
RNA expression pattern
	Top expressed in
	left ovary; ; body of pancreas; ; right ovary; ; ganglionic eminence; ; skin of abdomen; ; canal of the cervix; ; gastric mucosa; ; body of uterus; ; muscle layer of sigmoid colon; ; skin of leg;
	Top expressed in
	blastocyst; ; morula; ; embryo; ; embryo; ; ventricular zone; ; lip; ; yolk sac; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cadherin binding; RNA binding; structural constituent of ribosome;
Cellular component	cytosol; ribosome; membrane; intracellular anatomical structure; cytosolic large ribosomal subunit; extracellular exosome; postsynaptic density;
Biological process	viral transcription; SRP-dependent cotranslational protein targeting to membrane; ribosomal large subunit biogenesis; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; rRNA processing; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	9045
	67115
	ENSG00000188846
	ENSMUSG00000025794
	P50914
	Q9CR57
	NM_003973; NM_001034996
	NM_025974
	NP_001030168; NP_003964
	NP_080250
	Wikidata
View/Edit Human	View/Edit Mouse

60S ribosomal protein L14 is a protein that in humans is encoded by the RPL14 gene.^[5]^[6]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

Interactions

RPL14 has been shown to interact with PHLDA1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188846 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025794 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanaka M, Tanaka T, Harata M, Suzuki T, Mitsui Y (March 1998). "Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4)". Biochem Biophys Res Commun. 243 (2): 531–7. doi:10.1006/bbrc.1998.8125. PMID 9480843.
^ ^a ^b "Entrez Gene: RPL14 ribosomal protein L14".
^ Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. PMID 11369516.

External links

Human RPL14 genome location and RPL14 gene details page in the UCSC Genome Browser.

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