3,4-Difluoroamphetamine

3,4-Difluoroamphetamine

Identifiers
IUPAC name 1-(3-Chlorophenyl)-N-methylpropan-2-amine
CAS Number	31338-32-6
PubChem CID	11182888
ChemSpider	9357973
CompTox Dashboard (EPA)	DTXSID80457891
Chemical and physical data
Formula	C9H11F2N
Molar mass	171.191 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC(CC1=CC(=C(C=C1)F)F)N
InChI InChI=1S/C9H11F2N/c1-6(12)4-7-2-3-8(10)9(11)5-7/h2-3,5-6H,4,12H2,1H3 Key:GJEXOPSQWJWJRQ-UHFFFAOYSA-N

3,4-Difluoroamphetamine (DFA) is a substituted amphetamine which has been sold as a designer drug. It has relatively weak activity as a serotonin releasing agent with only around 1/4 of the affinity for the serotonin transporter compared to MDA, but its activity at other targets has not been studied.^[1][2]

See also

• 3-Fluoroamphetamine
• 3-Fluoromethamphetamine
• 4-Fluoroamphetamine
• 4-Fluoromethamphetamine
• 3,5-Difluoromethcathinone
• DFMDA
• DODC
• Xylopropamine

References

1. Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL (February 2004). "Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters". The Journal of Pharmacology and Experimental Therapeutics. 308 (2): 679–687. doi:10.1124/jpet.103.057836. PMID 14593087. S2CID 6439942.
2. Walline CC, Nichols DE, Carroll FI, Barker EL (June 2008). "Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition". The Journal of Pharmacology and Experimental Therapeutics. 325 (3): 791–800. doi:10.1124/jpet.108.136200. PMC 2637348. PMID 18354055.