The 2021-22 Malian Première Division was the 55th season of the highest level of professional football in Mali. The championship was contested by 18 teams, starting in November 2021 and finishing in July 2022. Stade Malien were the holders going into the season following their 23nd title in the 2020-21 season, but lost the title to Djoliba AC, who won their 23rd title and drew level with Stade Malien in overall championships won.
Overview
Unlike the 2020-21 season, which had two pools of 10 teams and a championship stage, the league went back to an 18 team home-and-away schedule for the 2021–22 season. The reduction from 20 clubs to 18 clubs meant that only two clubs (Afrique Football Elite and US Bougouba) were promoted from the second-tier to replace the four relegated teams from 2020 to 2021.
Updated to match(es) played on 17 August 2022. Source: Soccerway Rules for classification: 1) Points; 2) Goal Difference (C) Champions; (Q) Qualified for the phase indicated; (R) Relegated Notes:
^AS Real Bamako qualified for the CAF Confederation Cup as the 2021-22 Malian Cup runners-up