Note:Indiana State opted out of the spring season. † – Illinois State and Western Illinois opted out of the remainder of the spring season on March 21 and April 5, 2021, respectively.
North Dakota's game scheduled against Valparaiso was canceled on July 27 due to the Pioneer Football League's decision to play a conference-only schedule due to the COVID-19 pandemic.[1]
^On March 21, 2021, Illinois State announced that it would opt-out of the remainder of the 2021 spring season due to safety concerns related to the COVID-19 pandemic.