In the eight-finals, the first-placed team from one group faces the second-placed team from the other group. The eight winning teams advance to the quarterfinals. The four quarterfinal winners qualify for the semifinals and the winners of the semifinals qualify for the finals.
Times were CET/CEST,[note 1] as listed by LEN (local times, if different, are in parentheses).
The draw for the eight-finals was held on 16 December 2020.[5] The first legs were played on 27 February, and the second legs were played on 3 March 2021.
^CET (UTC+1) for dates up to 27 March 2021 (eight-finals, quarterfinals), and CEST (UTC+2) for dates thereafter (semifinals and finals).
^Strasbourg could not play for the first leg due to a player testing positive to COVID-19. However, the primary reason for the suspension was a mistake made a few days earlier. Strasbourg did not undergo the mandatory PCR test two days before entering the hotel (the first testing had to be done 72 hours before the match, on Wednesday). As a result, it was decided that the match should be played on one leg, at Serbia, on the original date of the second leg.[6]
