The game featured second-ranked Clemson of the Atlantic Coast Conference (ACC) against third-ranked Notre Dame, an FBS independent.[7] This was the first time that the two programs met in a bowl game; their more recent regular season meeting had been in 2015, won by Clemson.[7] The only prior Cotton Bowl to feature two undefeated teams had been the 1948 edition, which ended in a 13–13 tie between Penn State and SMU.[7]
Clemson defeated Pitt in the 2018 ACC Championship Game on December 1, then received their bid to the Cotton Bowl with the release of final CFP rankings on December 2.[7] The Tigers entered the bowl with a 13–0 record (8–0 in conference). On December 27, it was confirmed that three Clemson players, including starting defensive lineman Dexter Lawrence, would be suspended from playing in the game by the NCAA, due to drug testing showing "trace amounts of a banned substance", which was identified as ostarine.[8]
This was Clemson's second Cotton Bowl bid in school history, following its appearance in the 1940 edition. It was also the first Cotton Bowl appearance by an active ACC member since Maryland's appearance in the 1977 edition.
Notre Dame received their bid to the Cotton Bowl with the release of final CFP rankings on December 2.[7] The independent Fighting Irish entered the bowl with a 12–0 record. This was Notre Dame's first Cotton Bowl berth since the 1994 edition and its eighth overall.
There was a Cotton Bowl Classic in January and December in 1966, 2015, 2017, 2023, 2025.
The 2015 (December), 2018, 2021, and 2025 (January) editions were College Football Playoff semifinals.