The 2006 ACC Tournament was the first tournament with 12 teams participating. Boston College made its first appearance in the tournament, reaching the championship game before losing to Duke. 12th-seeded Wake Forest made a Cinderella run, beating 5th-seeded Florida State and 4th-seeded NC State on their way to the semifinal round, before losing to eventual champions Duke.
Miami and Boston College won their first ACC Tournament games in 2006. Miami defeated Clemson in the first round. Boston College defeated Maryland in the quarterfinal round.