TCU started off the season with a 17–10 victory over #7 ranked Oklahoma. It was Oklahoma's first home loss since 2001 and the first September loss for Oklahoma since Bob Stoops became head coach. About the loss running backAdrian Peterson said, "Right now, I'm kind of shocked." TCU held Peterson to 63 yards rushing and Oklahoma to 225 yards of total offense.[15]
On September 10, in the Battle for the Iron Skillet, TCU lost 21–10 to SMU. It was SMU's first victory over a ranked team since October 1, 1986. During the game, TCU had 4 turnovers to SMU's 1 turnover. TCU had beaten SMU six straight times before the loss. Placekicker Peter LoCoco missed three of his four field goal attempts during the game.[16]
TCU beat Utah 23–20 in overtime on September 15 in a Thursday night game. The victory ended Utah's 18-game winning streak.[17] TCU followed that game up with another overtime victory against BYU. TCU rallied from an 18-point deficit late in the third quarter to force overtime. With just under two minutes to go in the third quarter, BYU led 34–16, but TCU was able to outscore BYU 28–10 through the rest of regulation. In overtime, BYU missed an extra point attempt, after taking the lead on a touchdown. On TCU's ensuing possession, they managed to score a touchdown and score the conversion for the 51–50 victory.[18]
The BCS eligibility guidelines were revised following this season. Had they been in force during this season, TCU would have received an automatic bid to a BCS bowl.
TCU finished the year with a 27–24 victory in the 2005 Houston Bowl over Iowa State. The victory extended the Horned Frogs' winning streak to ten games. Peter LoCoco made 44-yard field goal with 5:25 left in the game to break a 24–24 tie. After the game, LoCoco said, "This is perfect. This is redemption. I'm glad I got the opportunity. This was a big confidence booster." He had missed three kicks in TCU's loss to SMU.[19]
TCU finished the year ranked #11 in the AP Poll and #9 in the Coaches' Poll, the only non-AQ conference team to be ranked in either final poll.[20]
^"TCU vs #5/7 Oklahoma". The Official Website of TCU Athletics. September 3, 2005. Retrieved February 12, 2010.
^"TCU vs SMU". The Official Website of TCU Athletics. September 10, 2005. Retrieved February 12, 2010.
^"Utah vs TCU". The Official Website of TCU Athletics. September 15, 2005. Archived from the original on February 29, 2012. Retrieved February 12, 2010.
^"TCU vs BYU". The Official Website of TCU Athletics. September 24, 2005. Archived from the original on February 29, 2012. Retrieved February 12, 2010.
^"New Mexico vs TCU". The Official Website of TCU Athletics. October 1, 2005. Archived from the original on February 29, 2012. Retrieved February 12, 2010.
^"TCU vs Wyoming". The Official Website of TCU Athletics. October 8, 2005. Retrieved February 12, 2010.
^"Army vs TCU". The Official Website of TCU Athletics. October 15, 2005. Archived from the original on February 29, 2012. Retrieved February 12, 2010.
^"TCU vs Air Force". The Official Website of TCU Athletics. October 22, 2005. Archived from the original on February 29, 2012. Retrieved February 12, 2010.
^"TCU vs San Diego State". The Official Website of TCU Athletics. October 29, 2005. Archived from the original on February 29, 2012. Retrieved February 12, 2010.
^"Colorado State vs TCU". The Official Website of TCU Athletics. November 5, 2005. Retrieved February 12, 2010.
^"UNLV vs TCU". The Official Website of TCU Athletics. November 12, 2005. Retrieved February 12, 2010.
^"TCU vs Iowa State". The Official Website of TCU Athletics. December 31, 2005. Archived from the original on February 29, 2012. Retrieved February 12, 2010.