The 2005 Saint Silvester Road Race (Portuguese: Corrida Internacional de São Silvestre de 2005) was the 81st edition of the Saint Silvester Road Race and held in São Paulo, Brazil, on December 31, 2005. The distance ran by the participating athletes was 15 km.
The podiums were composed of the first seven men and the first five women. The winners of both the men's event and the women's event received each a money prize of 21 thousand reais (approximately US$9 thousand).
For the amateur athletes participating (over 15 thousand in the men's event), there was an enrollment fee of 55 reais (US$23,50).