Virginia Wade defeated the defending champion Billie Jean King in the final, 6–4, 6–2 to win the women's singles tennis title at the 1968 US Open. It was her first major title.
This was the first edition of the tournament to be open to amateurs and professionals, marking a period known as the Open Era.
Seeds
The seeded players are listed below. Virginia Wade is the champion; others show the round in which they were eliminated.