The Conservative party selected as its candidate Violet Bathurst, Lady Apsley, who had married Lord Apsley in February 1942. During the Second World War the parties in the war-time Coalition Government had agreed not to contest any by-elections which occurred in seats held by Coalition parties. However, other parties and independents were free to stand, and some local parties fielded their own candidates as "independents" despite the truce. In Bristol Central, the former ILP MP Jennie Lee stood as an "Independent labour" candidate. The current ILP General Secretary, John McNair, also stood.
On a turnout less than half of that in the 1935 general election, Lady Apsley held the seat with a slightly increased majority.