VDR

VDR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DB1, 1IE8, 1IE9, 1KB2, 1KB4, 1KB6, 1S0Z, 1S19, 1TXI, 1YNW, 2HAM, 2HAR, 2HAS, 2HB7, 2HB8, 3A2I, 3A2J, 3A3Z, 3A40, 3A78, 3AUQ, 3AUR, 3AX8, 3AZ1, 3AZ2, 3AZ3, 3B0T, 3CS4, 3CS6, 3KPZ, 3M7R, 3OGT, 3P8X, 3TKC, 3VHW, 4G2I, 3W0A, 3W0C, 3W0Y, 3WGP, 3WWR, 4ITE, 4ITF, 4PA2, 3X31, 3X36, 4FHH, 4FHI, 2HBH
Dynodwyr
Cyfenwau	VDR, NR1I1, PPP1R163, vitamin D (1,25- dihydroxyvitamin D3) receptor, vitamin D receptor
Dynodwyr allanol	OMIM: 601769 HomoloGene: 37297 GeneCards: VDR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • lithocholic acid binding • sequence-specific DNA binding • DNA binding • lithocholic acid receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • steroid hormone receptor activity • GO:0001948, GO:0016582 protein binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • metal ion binding • vitamin D response element binding • retinoid X receptor binding • calcitriol binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • vitamin D binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • receptor complex • RNA polymerase II transcription regulator complex • cytoplasm Prosesau biolegol • negative regulation of cell population proliferation • positive regulation of apoptotic process involved in mammary gland involution • positive regulation of keratinocyte differentiation • regulation of calcidiol 1-monooxygenase activity • intestinal absorption • calcium ion transport • steroid hormone mediated signaling pathway • GO:0009373 regulation of transcription, DNA-templated • lactation • bile acid signaling pathway • animal organ morphogenesis • GO:0000767 cell morphogenesis • skeletal system development • GO:1901313 positive regulation of gene expression • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • multicellular organism development • negative regulation of keratinocyte proliferation • decidualization • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0045996 negative regulation of transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • positive regulation of vitamin D 24-hydroxylase activity • mammary gland branching involved in pregnancy • GO:0072468 signal transduction • cellular calcium ion homeostasis • transcription, DNA-templated • vitamin D receptor signaling pathway • vitamin D metabolic process • cell differentiation • intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7421	n/a
Ensembl	ENSG00000111424	n/a
UniProt	P11473	n/a
RefSeq (mRNA)	NM_000376 NM_001017535 NM_001017536 NM_001364085 NM_001374661 NM_001374662	n/a
RefSeq (protein)	NP_000367 NP_001017535 NP_001017536 NP_001351014 NP_001361590 NP_001361591	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VDR yw VDR a elwir hefyd yn Vitamin D3 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q13.11.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VDR.

• NR1I1
• PPP1R163

• "Vitamin D receptor (VDR) polymorphisms are associated to spontaneous preterm birth and maternal aspects. ". Gene. 2018. PMID 29128634.
• "Association between Vitamin D receptor (Cdx2, Fok1, Bsm1, Apa1, Bgl1, Taq1, and Poly (A)) gene polymorphism and breast cancer: A systematic review and meta-analysis. ". Tumour Biol. 2017. PMID 29072133.
• "Association of the vitamin D receptor FokI gene polymorphism with sex- and non-sex-associated cancers: A meta-analysis. ". Tumour Biol. 2017. PMID 29034815.
• "Genetic association analysis of vitamin D receptor gene polymorphisms and obesity-related phenotypes. ". Gene. 2018. PMID 29032145.
• "Association of vitamin D receptor gene polymorphisms with breast cancer risk in an Egyptian population.". Tumour Biol. 2017. PMID 29022486.