VCL

VCL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1RKC, 1RKE, 1SYQ, 1TR2, 2GWW, 2IBF, 3H2U, 3H2V, 3MYI, 3TJ5, 3TJ6, 3VF0, 4DJ9, 4EHP, 1YDI, 2HSQ, 3RF3, 3S90, 4LN2, 4LNP, 4PR9, 3JBK
Dynodwyr
Cyfenwau	VCL, CMD1W, CMH15, HEL114, MV, Mvinculin
Dynodwyr allanol	OMIM: 193065 HomoloGene: 7594 GeneCards: VCL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • beta-catenin binding • dystroglycan binding • structural molecule activity • GO:0001948, GO:0016582 protein binding • actin binding • alpha-catenin binding • ubiquitin protein ligase binding • cadherin binding Cydrannau o'r gell • cytoplasm • extracellular vesicle • cytosol • outer dense plaque of desmosome • bilen • cell-cell junction • focal adhesion • cell-substrate junction • adherens junction • cellbilen • inner dense plaque of desmosome • terminal web • extracellular region • cell junction • brush border • actin cytoskeleton • zonula adherens • membrane raft • fascia adherens • costamere • Cytosgerbwd • extracellular exosome • podosome • secretory granule lumen • specific granule lumen • ficolin-1-rich granule lumen • sarcolemma Prosesau biolegol • regulation of cell migration • muscle contraction • adherens junction assembly • epithelial cell-cell adhesion • platelet degranulation • morphogenesis of an epithelium • cell adhesion • negative regulation of cell migration • protein localization to cell surface • axon extension • cell-matrix adhesion • platelet aggregation • apical junction assembly • lamellipodium assembly • neutrophil degranulation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7414	n/a
Ensembl	ENSG00000035403	n/a
UniProt	P18206	n/a
RefSeq (mRNA)	NM_003373 NM_014000	n/a
RefSeq (protein)	NP_003364 NP_054706	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VCL yw VCL a elwir hefyd yn Vinculin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q22.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VCL.

• "Molecular Simulations Suggest a Force-Dependent Mechanism of Vinculin Activation. ". Biophys J. 2017. PMID 29045864.
• "Vinculin in cell-cell and cell-matrix adhesions. ". Cell Mol Life Sci. 2017. PMID 28401269.
• "An East Asian Common Variant Vinculin P.Asp841His Was Associated With Sudden Unexplained Nocturnal Death Syndrome in the Chinese Han Population. ". J Am Heart Assoc. 2017. PMID 28373245.
• "Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function. ". Gastroenterology. 2017. PMID 28342760.
• "Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites.". J Biol Chem. 2016. PMID 26728462.