VAV3

VAV3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2D86
Dynodwyr
Cyfenwau	VAV3, vav guanine nucleotide exchange factor 3
Dynodwyr allanol	OMIM: 605541 HomoloGene: 38143 GeneCards: VAV3
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • metal ion binding; • epidermal growth factor receptor binding; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • guanyl-nucleotide exchange factor activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • cellbilen;
Prosesau biolegol	• angiogenesis; • Fc-gamma receptor signaling pathway involved in phagocytosis; • GO:0007243 intracellular signal transduction; • ephrin receptor signaling pathway; • lamellipodium assembly; • regulation of Rho protein signal transduction; • positive regulation of phosphatidylinositol 3-kinase activity; • vascular endothelial growth factor receptor signaling pathway; • small GTPase mediated signal transduction; • B cell receptor signaling pathway; • cell projection assembly; • Fc-epsilon receptor signaling pathway; • positive regulation of apoptotic process; • integrin-mediated signaling pathway; • cellular response to DNA damage stimulus; • regulation of cell size; • regulation of small GTPase mediated signal transduction; • cell migration; • platelet activation; • vesicle fusion; • positive regulation of cell adhesion; • positive regulation of B cell proliferation; • neutrophil chemotaxis; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • positive regulation of signal transduction; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	10451
	n/a
	ENSG00000134215
	n/a
	Q9UKW4
	n/a
	NM_001079874; NM_006113
	n/a
	NP_001073343; NP_006104
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VAV3 yw VAV3 a elwir hefyd yn Vav guanine nucleotide exchange factor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p13.3.^[2]

Llyfryddiaeth

"VAV3 oncogene expression in colorectal cancer: clinical aspects and functional characterization. ". Sci Rep. 2015. PMID 25791293.
"VAV3 Overexpressed in Cancer Stem Cells Is a Poor Prognostic Indicator in Ovarian Cancer Patients. ". Stem Cells Dev. 2015. PMID 25715123.
"Vav3 is linked to poor prognosis of pancreatic cancers and promotes the motility and invasiveness of pancreatic cancer cells. ". Pancreatology. 2016. PMID 27453460.
"VAV3 Gene Polymorphism Is Associated with Paget's Disease of Bone. ". Genet Test Mol Biomarkers. 2016. PMID 27172236.
"Differential Gene Expression of the Proto-oncogene VAV3 and the Transcript Variant VAV3.1 in Oral Squamous Cell Carcinoma.". Anticancer Res. 2015. PMID 25964534.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] VAV3 - Cronfa NCBI

[1]

[2]

VAV3

Llyfryddiaeth

Cyfeiriadau

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