UBE2B

UBE2B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JAS, 2Y4W, 2YB6, 2YBF
Dynodwyr
Cyfenwau	UBE2B, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2, ubiquitin conjugating enzyme E2 B
Dynodwyr allanol	OMIM: 179095 HomoloGene: 101298 GeneCards: UBE2B
EC number	2.3.2.23
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding • ATP binding • ubiquitin conjugating enzyme activity • ubiquitin protein ligase binding Cydrannau o'r gell • cytoplasm • bilen • cellbilen • replication fork • HULC complex • nucleoplasm • XY body • chromatin • cnewyllyn cell Prosesau biolegol • chiasma assembly • histone H2A ubiquitination • negative regulation of cAMP-mediated signaling • postreplication repair • ubiquitin-dependent protein catabolic process • protein K63-linked ubiquitination • meiotic telomere clustering • positive regulation of reciprocal meiotic recombination • protein stabilization • protein polyubiquitination • negative regulation of apoptotic process • in utero embryonic development • protein monoubiquitination • sperm axoneme assembly • cellular response to DNA damage stimulus • protein K11-linked ubiquitination • histone lysine demethylation • protein K48-linked ubiquitination • GO:0033127, GO:2000281, GO:2000817 regulation of histone modification • spermatogenesis • canonical Wnt signaling pathway • synaptonemal complex organization • response to UV • proteasome-mediated ubiquitin-dependent protein catabolic process • protein autoubiquitination • GO:0100026 DNA repair • protein ubiquitination • positive regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7320	n/a
Ensembl	ENSG00000119048	n/a
UniProt	P63146	n/a
RefSeq (mRNA)	NM_003337	n/a
RefSeq (protein)	NP_003328	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBE2B yw UBE2B a elwir hefyd yn Ubiquitin conjugating enzyme E2 B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q31.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBE2B.

• "UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men. ". Mol Hum Reprod. 2013. PMID 23378580.
• "Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population. ". Genet Mol Res. 2012. PMID 23079972.
• "Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs. ". J Biol Chem. 2017. PMID 28490629.
• "Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer. ". Biochem Biophys Res Commun. 2016. PMID 26679603.
• "A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia.". Reprod Biol Endocrinol. 2015. PMID 26223869.