TPMT

TPMT
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2BZG, 2H11
Dynodwyr
Cyfenwau	TPMT, entrez:7172, TPMTD, thiopurine S-methyltransferase
Dynodwyr allanol	OMIM: 187680 HomoloGene: 313 GeneCards: TPMT
EC number	2.1.1.67
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • S-adenosylmethionine-dependent methyltransferase activity • transferase activity • GO:0102674, GO:0102675 methyltransferase activity • thiopurine S-methyltransferase activity • S-adenosyl-L-methionine binding Cydrannau o'r gell • cytosol • cytoplasm Prosesau biolegol • nucleobase-containing compound metabolic process • methylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7172	n/a
Ensembl	ENSG00000137364	n/a
UniProt	P51580	n/a
RefSeq (mRNA)	NM_000367 NM_001346817 NM_001346818	n/a
RefSeq (protein)	NP_000358 NP_001333746 NP_001333747	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TPMT yw TPMT a elwir hefyd yn Thiopurine S-methyltransferase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p22.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TPMT.

• TPMTD

• "Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods. ". Cardiovasc Hematol Agents Med Chem. 2017. PMID 28552060.
• "Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients. ". Arch Med Res. 2016. PMID 28476189.
• "Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies. ". Clin Pharmacol Ther. 2017. PMID 27770449.
• "Frequency of thiopurine methyltransferase mutation in patients of Mediterranean area with inflammatory bowel disease and autoimmune disorders. ". Dig Liver Dis. 2016. PMID 27665263.
• "Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.". Clin Pharmacol Ther. 2017. PMID 27564568.