TP73

TP73
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4GUQ, 1COK, 1DXS, 2KBY, 2MPS, 2WQI, 2WQJ, 2WTT, 2XWC, 3VD0, 3VD1, 3VD2, 4A63, 4G82, 4G83, 4GUO
Dynodwyr
Cyfenwau	TP73, P73, tumor protein p73, CILD47
Dynodwyr allanol	OMIM: 601990 HomoloGene: 3960 GeneCards: TP73
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor binding; • chromatin binding; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • damaged DNA binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • protein kinase binding; • p53 binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • MDM2/MDM4 family protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • Golgi apparatus; • intracellular membrane-bounded organelle; • transcription regulator complex; • cell junction; • chromatin; • cnewyllyn cell; • mitocondria; • nucleoplasm; • cytosol;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • positive regulation of oligodendrocyte differentiation; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of neuron differentiation; • kidney development; • cellular response to UV; • GO:1901227 negative regulation of transcription by RNA polymerase II; • protein tetramerization; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • mitotic G1 DNA damage checkpoint signaling; • response to organonitrogen compound; • intrinsic apoptotic signaling pathway in response to DNA damage; • regulation of mitotic cell cycle; • positive regulation of apoptotic process; • regulation of gene expression; • DNA mismatch repair; • cell cycle; • negative regulation of cardiac muscle cell proliferation; • GO:0022415 viral process; • negative regulation of JUN kinase activity; • response to gamma radiation; • response to X-ray; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • negative regulation of cell population proliferation; • GO:0097285 apoptotic process; • regulation of signal transduction by p53 class mediator; • transcription by RNA polymerase II; • regulation of apoptotic process; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologau
	7161
	n/a
	ENSG00000078900
	n/a
	O15350
	n/a
NM_001126240; NM_001126241; NM_001126242; NM_001204184; NM_001204185;
	NM_001204186; NM_001204187; NM_001204188; NM_001204189; NM_001204190; NM_001204191; NM_001204192; NM_005427
	n/a
NP_001119712; NP_001119713; NP_001119714; NP_001191113; NP_001191114;
	NP_001191115; NP_001191116; NP_001191117; NP_001191118; NP_001191119; NP_001191120; NP_001191121; NP_005418
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TP73 yw TP73 a elwir hefyd yn Tumor protein p73 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TP73.

P73

Llyfryddiaeth

"Aberration of p73Promoter Methylation in Chondrosarcoma. ". Anticancer Res. 2017. PMID 28551631.
"Trifluoroethanol-induced conformational transition of the C-terminal sterile alpha motif (SAM) of human p73. ". Arch Biochem Biophys. 2017. PMID 28235466.
"Meta-analysis of TP73 polymorphism and cervical cancer. ". Genet Mol Res. 2017. PMID 28128397.
"Decreased expression of p73 in colorectal cancer. ". Folia Histochem Cytobiol. 2016. PMID 27654017.
"The polymorphism G4C14-to-A4T14 in p73 gene may affect the susceptibility to male infertility with severe spermatogenesis impairment in Chinese population.". Eur J Obstet Gynecol Reprod Biol. 2016. PMID 27525684.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TP73 - Cronfa NCBI

[1]

[2]

TP73

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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