TJP1

TJP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2H2B, 2H2C, 2H3M, 2JWE, 2KXR, 2KXS, 2RCZ, 3CYY, 3LH5, 3SHU, 3SHW, 3TSV, 3TSW, 3TSZ, 4OEO, 4OEP, 4Q2Q, 4YYX
Dynodwyr
Cyfenwau	TJP1, ZO-1, Tight junction protein 1
Dynodwyr allanol	OMIM: 601009 HomoloGene: 2445 GeneCards: TJP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calmodulin binding • GO:0001948, GO:0016582 protein binding • cadherin binding • protein domain specific binding • connexin binding • protein C-terminus binding Cydrannau o'r gell • bilen • bicellular tight junction • cellbilen • basolateral plasma membrane • gap junction • apical junction complex • cytosol • cytoplasm • apical part of cell • cell junction • podosome • cell projection • cnewyllyn cell • cell-cell junction • adherens junction • intercalated disc • apical plasma membrane • apicolateral plasma membrane • intercellular canaliculus • tight junctions • GO:0009327 protein-containing complex Prosesau biolegol • establishment of endothelial intestinal barrier • hippo signaling • cell-cell junction assembly • regulation of bicellular tight junction assembly • blastocyst formation • clyw • response to lipopolysaccharide • negative regulation of vascular permeability • response to ethanol • response to magnetism • cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7082	n/a
Ensembl	ENSG00000277401 ENSG00000104067	n/a
UniProt	Q07157	n/a
RefSeq (mRNA)	NM_001301025 NM_001301026 NM_003257 NM_175610 NM_001330239 NM_001355012 NM_001355013 NM_001355014 NM_001355015	n/a
RefSeq (protein)	NP_001287954 NP_001287955 NP_001317168 NP_003248 NP_783297 NP_001341941 NP_001341942 NP_001341943 NP_001341944 NP_001287954.1 NP_001287955.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TJP1 yw TJP1 a elwir hefyd yn Tight junction protein 1 (Zona occludens 1), isoform CRA_a a Tight junction protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q13.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TJP1.

• ZO-1

• "Cytokine-mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium. ". Microvasc Res. 2015. PMID 25953589.
• "Identification and dynamic regulation of tight junction protein expression in human neural stem cells. ". Stem Cells Dev. 2015. PMID 25892136.
• "ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture. ". J Cell Sci. 2017. PMID 27802160.
• "Novel role of zonula occludens-1: A tight junction protein closely associated with the odontoblast differentiation of human dental pulp cells. ". Cell Biol Int. 2016. PMID 27109589.
• "[High frequency of ancestral allele of the TJP1 polymorphism rs2291166 in Mexican population, conformational effect and applications in surgery and medicine].". Cir Cir. 2016. PMID 26259745.