TGM2

TGM2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4PYG, 1KV3, 2Q3Z, 3LY6, 3S3J, 3S3P, 3S3S
Dynodwyr
Cyfenwau	TGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h), hTG2, tTG
Dynodwyr allanol	OMIM: 190196 HomoloGene: 3391 GeneCards: TGM2
EC number	3.5.1.44 2.3.2.13, 3.5.1.44
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • acyltransferase activity • protein-glutamine gamma-glutamyltransferase activity • GO:0001948, GO:0016582 protein binding • metal ion binding • GTP binding • protein domain specific binding Cydrannau o'r gell • cytoplasm • intrinsic component of plasma membrane • cytosol • extracellular exosome • focal adhesion • mitocondria • Reticwlwm endoplasmig • cellbilen • GO:0005578 extracellular matrix • collagen-containing extracellular matrix Prosesau biolegol • apoptotic cell clearance • phospholipase C-activating G protein-coupled receptor signaling pathway • salivary gland cavitation • negative regulation of endoplasmic reticulum calcium ion concentration • positive regulation of mitochondrial calcium ion concentration • GO:0051357, GO:0051358, GO:0051359 peptide cross-linking • positive regulation of cell adhesion • branching involved in salivary gland morphogenesis • positive regulation of inflammatory response • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine • positive regulation of apoptotic process • protein homooligomerization • positive regulation of smooth muscle cell proliferation • blood vessel remodeling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7052	n/a
Ensembl	ENSG00000198959	n/a
UniProt	P21980	n/a
RefSeq (mRNA)	NM_004613 NM_198951 NM_001323316 NM_001323317 NM_001323318	n/a
RefSeq (protein)	NP_001310245 NP_001310246 NP_001310247 NP_004604 NP_945189	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TGM2 yw TGM2 a elwir hefyd yn Transglutaminase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20q11.23.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TGM2.

• TGC
• TG(C)

• "Associations of tissue transglutaminase antibody seropositivity with coronary heart disease: Findings from a prospective cohort study. ". Nutr Metab Cardiovasc Dis. 2017. PMID 28756971.
• "Transglutaminase 2 is upregulated in primary hepatocellular carcinoma with early recurrence as determined by proteomic profiles. ". Int J Oncol. 2017. PMID 28339069.
• "Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2. ". PLoS One. 2017. PMID 28248968.
• "Tissue transglutaminase induces Epithelial-Mesenchymal-Transition and the acquisition of stem cell like characteristics in colorectal cancer cells. ". Oncotarget. 2017. PMID 28223538.
• "Value of IgA tTG in Predicting Mucosal Recovery in Children With Celiac Disease on a Gluten-Free Diet.". J Pediatr Gastroenterol Nutr. 2017. PMID 28112686.