TGFB3

TGFB3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KTZ, 1TGJ, 1TGK, 2PJY, 3EO1, 4UM9
Dynodwyr
Cyfenwau	TGFB3, ARVD, ARVD1, RNHF, TGF-beta3, Transforming growth factor, beta 3, LDS5, transforming growth factor beta 3, TGF beta 3
Dynodwyr allanol	OMIM: 190230 HomoloGene: 2433 GeneCards: TGFB3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • type III transforming growth factor beta receptor binding • cytokine activity • type I transforming growth factor beta receptor binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • transforming growth factor beta receptor binding • growth factor activity • transforming growth factor beta binding • type II transforming growth factor beta receptor binding • identical protein binding Cydrannau o'r gell • cytoplasm • GO:0005578 extracellular matrix • T-tubule • cellbilen • secretory granule • cell surface • soma • platelet alpha granule lumen • cnewyllyn cell • extracellular region • extracellular space • intracellular membrane-bounded organelle • collagen-containing extracellular matrix Prosesau biolegol • regulation of apoptotic process • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of collagen biosynthetic process • cell-cell junction organization • regulation of MAPK cascade • SMAD protein signal transduction • positive regulation of bone mineralization • embryonic neurocranium morphogenesis • response to progesterone • female pregnancy • response to laminar fluid shear stress • GO:0010260 heneiddio • platelet degranulation • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • wound healing • salivary gland morphogenesis • mammary gland development • odontogenesis • response to estrogen • positive regulation of protein secretion • ossification involved in bone remodeling • uterine wall breakdown • frontal suture morphogenesis • inner ear development • negative regulation of macrophage cytokine production • lung alveolus development • digestive tract development • transforming growth factor beta receptor signaling pathway • positive regulation of filopodium assembly • positive regulation of cell division • face morphogenesis • detection of hypoxia • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of SMAD protein signal transduction • positive regulation of tight junction disassembly • positive regulation of epithelial to mesenchymal transition • positive regulation of stress fiber assembly • regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of apoptotic process • response to hypoxia • positive regulation of pathway-restricted SMAD protein phosphorylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of vascular associated smooth muscle cell proliferation • BMP signaling pathway • cell development • regulation of signaling receptor activity • positive regulation of cell population proliferation • negative regulation of cell population proliferation • secondary palate development • regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7043	n/a
Ensembl	ENSG00000119699	n/a
UniProt	P10600	n/a
RefSeq (mRNA)	NM_003239 NM_001329938 NM_001329939	n/a
RefSeq (protein)	NP_001316867 NP_001316868 NP_003230	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TGFB3 yw TGFB3 a elwir hefyd yn Transforming growth factor beta 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q24.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TGFB3.

• "Mesenchymal stem cells suppress fibroblast proliferation and reduce skin fibrosis through a TGF-β3-dependent activation. ". Int J Low Extrem Wounds. 2015. PMID 25858630.
• "Mutations in a TGF-β ligand, TGFB3, cause syndromic aortic aneurysms and dissections. ". J Am Coll Cardiol. 2015. PMID 25835445.
• "TGFß3 / SfaN1 gene variant and the risk factor of nonsyndromic cleft palate only among Indonesian patients. ". Cell Mol Biol (Noisy-le-grand). 2017. PMID 28364787.
• "Influence of vitamin D and transforming growth factor β3 serum concentrations, obesity, and family history on the risk for uterine fibroids. ". Fertil Steril. 2016. PMID 27743697.
• "Exome sequencing identifies a novel heterozygous TGFB3 mutation in a disorder overlapping with Marfan and Loeys-Dietz syndrome.". Mol Cell Probes. 2015. PMID 26184463.