TGFB2

TGFB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TFG, 2TGI, 4KXZ
Dynodwyr
Cyfenwau	TGFB2, TGF-beta2, transforming growth factor beta 2, G-TSF
Dynodwyr allanol	OMIM: 190220 HomoloGene: 2432 GeneCards: TGFB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • type II transforming growth factor beta receptor binding • signaling receptor binding • type III transforming growth factor beta receptor binding • cytokine activity • transforming growth factor beta receptor binding • growth factor activity • protein homodimerization activity • amyloid-beta binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity Cydrannau o'r gell • extracellular region • GO:0005578 extracellular matrix • platelet alpha granule lumen • extracellular space • axon • soma • collagen-containing extracellular matrix Prosesau biolegol • eye development • regulation of transforming growth factor beta2 production • response to progesterone • marwolaeth celloedd • cardioblast differentiation • positive regulation of integrin biosynthetic process • protein phosphorylation • positive regulation of heart contraction • positive regulation of neuron apoptotic process • angiogenesis • negative regulation of epithelial cell proliferation • uterine wall breakdown • negative regulation of alkaline phosphatase activity • negative regulation of macrophage cytokine production • positive regulation of cell adhesion mediated by integrin • cell population proliferation • transforming growth factor beta receptor signaling pathway • negative regulation of cell population proliferation • positive regulation of stress-activated MAPK cascade • cell-cell junction organization • extrinsic apoptotic signaling pathway • collagen fibril organization • positive regulation of epithelial cell migration • neutrophil chemotaxis • positive regulation of cell growth • response to wounding • negative regulation of cell growth • positive regulation of cardioblast differentiation • glial cell migration • wound healing • positive regulation of ossification • cardiac muscle cell proliferation • positive regulation of epithelial to mesenchymal transition • odontogenesis • positive regulation of timing of catagen • positive regulation of immune response • regulation of complement-dependent cytotoxicity • positive regulation of protein secretion • epithelial to mesenchymal transition • embryonic digestive tract development • response to hypoxia • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • heart morphogenesis • platelet degranulation • salivary gland morphogenesis • generation of neurons • negative regulation of immune response • GO:0000767 cell morphogenesis • positive regulation of cell population proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • cell migration • activation of protein kinase activity • positive regulation of cell division • cardiac epithelial to mesenchymal transition • BMP signaling pathway • cell development • skeletal system development • kidney development • neural tube closure • hair follicle development • outflow tract septum morphogenesis • membranous septum morphogenesis • heart valve morphogenesis • atrioventricular valve morphogenesis • pulmonary valve morphogenesis • endocardial cushion morphogenesis • cardiac right ventricle morphogenesis • ventricular trabecula myocardium morphogenesis • endocardial cushion fusion • atrial septum primum morphogenesis • neural retina development • development of the heart • male gonad development • hemopoiesis • embryonic limb morphogenesis • hair follicle morphogenesis • ascending aorta morphogenesis • dopamine biosynthetic process • positive regulation of cell cycle • negative regulation of Ras protein signal transduction • somatic stem cell division • neuron development • inner ear development • uterus development • pathway-restricted SMAD protein phosphorylation • ventricular septum morphogenesis • atrial septum morphogenesis • pharyngeal arch artery morphogenesis • regulation of apoptotic process involved in outflow tract morphogenesis • substantia propria of cornea development • cranial skeletal system development • negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • regulation of signaling receptor activity • negative regulation of gene expression • negative regulation of angiogenesis • positive regulation of Notch signaling pathway • SMAD protein signal transduction • positive regulation of pri-miRNA transcription by RNA polymerase II • embryo development ending in birth or egg hatching • regulation of timing of catagen • secondary palate development • regulation of cell population proliferation • regulation of apoptotic process • regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7042	n/a
Ensembl	ENSG00000092969	n/a
UniProt	P61812	n/a
RefSeq (mRNA)	NM_003238 NM_001135599	n/a
RefSeq (protein)	NP_001129071 NP_003229	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TGFB2 yw TGFB2 a elwir hefyd yn Transforming growth factor beta 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q41.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TGFB2.

• LDS4
• G-TSF
• TGF-beta2

• "Cell proliferation downregulated by TGF-β2-triggered G1/S checkpoint in clinical CAFs. ". Cell Cycle. 2017. PMID 27880067.
• "Genetic variance of transforming growth factor β2 gene in conotruncal heart defects. ". Biomarkers. 2017. PMID 27564654.
• "Phenotypic variability and diffuse arterial lesions in a family with Loeys-Dietz syndrome type 4. ". Clin Genet. 2017. PMID 27440102.
• "AGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells: implications for age-associated fibrosis. ". Aging Cell. 2016. PMID 26853893.
• "Rho GTPase signaling promotes constitutive expression and release of TGF-β2 by human trabecular meshwork cells.". Exp Eye Res. 2016. PMID 26743044.