TAF1

TAF1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1EQF, 3AAD, 3UV4, 3UV5, 4RGW, 4YYM, 4YYN, 5I29, 5I1Q, 5FUR
Dynodwyr
Cyfenwau	TAF1, BA2R, CCG1, CCGS, DYT3, DYT3/KAT4, N-NSCL2, OF, P250, TAF(II)250, TAF2A, TAFII-250, TAFII250, XDP, MRXS33, TATA-box binding protein associated factor 1
Dynodwyr allanol	OMIM: 313650 HomoloGene: 37942 GeneCards: TAF1
EC number	2.7.11.1 2.3.1.48, 2.7.11.1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • DNA binding; • GO:0001105 transcription coactivator activity; • p53 binding; • transcription factor binding; • GO:0001948, GO:0016582 protein binding; • lysine-acetylated histone binding; • TBP-class protein binding; • acyltransferase activity; • ATP binding; • protein serine/threonine kinase activity; • histone acetyltransferase activity; • kinase activity; • protein heterodimerization activity; • H3K27me3 modified histone binding; • ubiquitin conjugating enzyme activity; • acetyl-CoA binding; • sequence-specific DNA binding; • RNA polymerase II core promoter sequence-specific DNA binding; • RNA polymerase II-specific DNA-binding transcription factor binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000983 RNA polymerase II general transcription initiation factor activity;
Cydrannau o'r gell	• nucleoplasm; • MLL1 complex; • cnewyllyn cell; • nucleolus; • transcription regulator complex; • transcription factor TFIID complex;
Prosesau biolegol	• phosphorylation; • RNA polymerase II preinitiation complex assembly; • transcription by RNA polymerase II; • positive regulation of transcription initiation from RNA polymerase II promoter; • transcription, DNA-templated; • GO:0035404 peptidyl-serine phosphorylation; • DNA-templated transcription, initiation; • protein autophosphorylation; • cell cycle; • transcription initiation from RNA polymerase II promoter; • peptidyl-threonine phosphorylation; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • regulation of signal transduction by p53 class mediator; • GO:0022415 viral process; • histone acetylation; • protein polyubiquitination; • protein phosphorylation; • cellular response to DNA damage stimulus; • negative regulation of gene expression; • midbrain development; • positive regulation of protein binding; • cellular response to UV; • transcription factor catabolic process; • protein stabilization; • regulation of transcription initiation from RNA polymerase II promoter; • cellular response to ATP; • regulation of cell cycle G1/S phase transition; • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; • negative regulation of protein autoubiquitination; • negative regulation of ubiquitin-dependent protein catabolic process; • positive regulation of androgen receptor activity; • positive regulation of transcription by RNA polymerase I; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; • negative regulation of DNA-binding transcription factor activity; • ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologau
	6872
	n/a
	ENSG00000147133
	n/a
	P21675
	n/a
	NM_001286074; NM_004606; NM_138923
	n/a
	NP_001273003; NP_004597; NP_620278
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TAF1 yw TAF1 a elwir hefyd yn TATA-box binding protein associated factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TAF1.

OF
XDP
BA2R
CCG1
CCGS
DYT3
KAT4
P250
NSCL2
TAF2A
MRXS33
N-TAF1
TAFII250
DYT3/TAF1
TAFII-250
TAF(II)250

Llyfryddiaeth

X-Linked Dystonia-Parkinsonism. 1993. PMID 20301662.
"The monogenic primary dystonias. ". Brain. 2009. PMID 19578124.
"Evidence of TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism. ". Cell Mol Life Sci. 2016. PMID 26879577.
"Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells. ". Dis Model Mech. 2016. PMID 26769797.
"TAFI gene polymorphisms in patients with cerebral venous thrombosis.". Acta Neurol Belg. 2013. PMID 23264082.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TAF1 - Cronfa NCBI

[1]

[2]

TAF1

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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