TAC1

TAC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KS9, 2KSA, 2KSB, 4HOM,%%s2B19,%%s2B19
Dynodwyr
Cyfenwau	TAC1, Hs.2563, NK2, TAC2, tachykinin precursor 1, NKNA, NPK
Dynodwyr allanol	OMIM: 162320 HomoloGene: 2394 GeneCards: TAC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • signaling receptor binding • substance P receptor binding Cydrannau o'r gell • cellbilen • extracellular region • axon • soma • extracellular space Prosesau biolegol • cellular response to nerve growth factor stimulus • response to yeast • associative learning • positive regulation of renal sodium excretion • positive regulation of cytosolic calcium ion concentration • cell-cell signaling • antibacterial humoral response • positive regulation of synaptic transmission, cholinergic • positive regulation of epithelial cell migration • positive regulation of ossification • positive regulation of synaptic transmission, GABAergic • negative regulation of heart rate • positive regulation of corticosterone secretion • regulation of blood pressure • positive regulation of action potential • response to morphine • response to lipopolysaccharide • long-term memory • response to pain • GO:0051636 defense response to Gram-negative bacterium • positive regulation of saliva secretion • positive regulation of acute inflammatory response • insemination • response to hormone • sensory perception of pain • detection of abiotic stimulus • innate immune response • neuropeptide signaling pathway • positive regulation of lymphocyte proliferation • positive regulation of stress fiber assembly • antifungal humoral response • GO:0051637 defense response to Gram-positive bacterium • chemical synaptic transmission • inflammatory response • tachykinin receptor signaling pathway • antimicrobial humoral immune response mediated by antimicrobial peptide • killing of cells of other organism • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6863	n/a
Ensembl	ENSG00000006128	n/a
UniProt	P20366	n/a
RefSeq (mRNA)	NM_013998 NM_003182 NM_013996 NM_013997	n/a
RefSeq (protein)	NP_003173 NP_054702 NP_054703 NP_054704	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TAC1 yw TAC1 a elwir hefyd yn Tachykinin precursor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q21.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TAC1.

• "Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis. ". J Neuroimmune Pharmacol. 2015. PMID 25690155.
• "Substance P is upregulated in the serum of patients with chronic spontaneous urticaria. ". J Invest Dermatol. 2014. PMID 24844859.
• "Substance P enhances proliferation and paracrine potential of adipose-derived stem cells in vitro. ". Biochem Biophys Res Commun. 2017. PMID 28192115.
• "Serum substance P concentrations to predict oocyte maturation index and clinical pregnancy. ". Gynecol Endocrinol. 2017. PMID 27908224.
• "Raised circulating Neurokinin A predicts prognosis in metastatic small bowel neuroendocrine tumours. Lowering Neurokinin A indicates improved prognosis.". Ann Clin Biochem. 2016. PMID 26038607.