SPSB1

SPSB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2JK9, 3F2O
Dynodwyr
Cyfenwau	SPSB1, SSB-1, SSB1, splA/ryanodine receptor domain and SOCS box containing 1
Dynodwyr allanol	OMIM: 611657 HomoloGene: 11832 GeneCards: SPSB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • GO:0050372 ubiquitin-protein transferase activity • ubiquitin ligase-substrate adaptor activity Cydrannau o'r gell • cytoplasm • cytosol • SCF ubiquitin ligase complex Prosesau biolegol • protein ubiquitination • protein polyubiquitination • post-translational protein modification • ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	80176	n/a
Ensembl	ENSG00000171621	n/a
UniProt	Q96BD6	n/a
RefSeq (mRNA)	NM_025106	n/a
RefSeq (protein)	NP_079382	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPSB1 yw SPSB1 a elwir hefyd yn SplA/ryanodine receptor domain and SOCS box containing 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.22.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPSB1.

• SSB1
• SSB-1

• "The ECS(SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase. ". Biochem Biophys Res Commun. 2011. PMID 21549100.
• "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. ". J Biol Chem. 2005. PMID 15713673.
• "SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling. ". Cell Res. 2017. PMID 28084329.
• "SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. ". Cancer Discov. 2014. PMID 24786206.
• "SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor.". J Biol Chem. 2015. PMID 26032413.