SPRED2

SPRED2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2JP2
Dynodwyr
Cyfenwau	SPRED2, Spred-2, sprouty related EVH1 domain containing 2, NS14
Dynodwyr allanol	OMIM: 609292 HomoloGene: 24918 GeneCards: SPRED2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein kinase binding • protein serine/threonine kinase inhibitor activity • stem cell factor receptor binding Cydrannau o'r gell • cytoplasm • cellbilen • transport vesicle membrane • bilen • GO:0016023 cytoplasmic vesicle • cytosol Prosesau biolegol • multicellular organism development • negative regulation of peptidyl-threonine phosphorylation • regulation of signal transduction • fibroblast growth factor receptor signaling pathway • regulation of protein deacetylation • positive regulation of DNA damage response, signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	200734	n/a
Ensembl	ENSG00000198369	n/a
UniProt	Q7Z698	n/a
RefSeq (mRNA)	NM_001128210 NM_181784	n/a
RefSeq (protein)	NP_001121682 NP_861449	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPRED2 yw SPRED2 a elwir hefyd yn Sprouty related EVH1 domain containing 2 a Sprouty-related, EVH1 domain-containing protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2p14.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPRED2.

• Spred-2

• "1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain. ". J Biomol NMR. 2004. PMID 15213456.
• "Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation. ". Int J Biochem Cell Biol. 2012. PMID 22305891.
• "Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death. ". Oncotarget. 2016. PMID 27028858.
• "Spred2 modulates the erythroid differentiation induced by imatinib in chronic myeloid leukemia cells. ". PLoS One. 2015. PMID 25688862.
• "Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism.". Biochem Biophys Res Commun. 2011. PMID 21703232.